Teacher-researcher (assistant professor)
Teaching in cognitive neurosciences at the Institute for Clinical and Science Rehabilitation (Lyon 1 University) and at Lyon 2 University (Cognitive Sciences and FPP)
Co-responsible for one Master 2 in Clinical and Science Rehabilitation (Lyon 1 University)
Responsible for the 3D Brain 3 pedagogical team: cerveau3d.univ-lyon1.fr
Co-head of the Auditory Cognition and Psychoacoustics team at the Lyon Neuroscience Research Centre
Research projects
The projects focus on the cerebral and cognitive mechanisms associated with unconscious auditory perception. Auditory perception is studied during sleep, using subliminal stimulations and in patients with consciousness disorders (coma, awakening from coma). A multidisciplinary approach is favoured by using cognitive neuroscience, psychoacoustics, cognitive psychology, clinical and engineering methodologies: behavioural measurements (scales, videos), electroencephalographic (hd-EEG) and debimetric (fMRI) measurements are used.
The main topics are:
- The effects of music on cognition in patients with a disorder of consciousness (Collaboration with Lizette Heine -CRNL, Jacques Luauté -HCL)
- The evaluation of cognitive and cerebral functions of patients with a disorder of consciousness (Collaboration with Jacques Luauté -HCL, Alexandra Corneyllie, Lizette Heine -CRNL, Stein Silva -CHU Toulouse, Claire Sergent - INC Paris, L Naccache -ICM Paris)
- The evaluation of cognitive and cerebral functions of patients with delirium (Fabrice Ferré, Stein Silva - CHU Toulouse)
- The study of the dynamic of brain-body-environment interactions recovery during consciousness recovery (Raphaël Minjard -CRPPC, Stefen Duffner -INSA)
- The study of the dynamic of circadian rhythms recovery (biological, hormonal and cerebral) during consciousness recovery (Florent Gobert, Jacques Luauté -HCL)
- The effect of sound externalization on cognition and the study of spatio-corporal representations in auditory perception (Mathieu Lavandier -ENTPE)
- The exploration of hearing deficits associated with schizophrenia (Collaboration Psyr2, ENTPE, CAP)
Publications (* co-autorship)
Sautet A, Hurtado L, Fiveash A, Baron L, De Quelen M, Perrin F. The importance of material used in speech therapy: two case studies in minimally conscious state patients. Brain Sciences 2022, 12: 483. doi : 10.3390/brainsci12040483.
Corneyllie A, Perrin F*, Heine L*. Sharing an open stimulation system for auditory EEG experiments using Python, Raspberry Pi and HifiBerry. eNeuro 2021, 8 (4): ENEURO.0524-20.2021. doi: 10.1523/ENEURO.0524-20.2021.
Heine L, Corneyllie A, Luauté J, Lavandier M, Perrin F. Virtually spatialized sounds enhance auditory processing in healthy participants and patients with a disorder of consciousness. Scientific Report 2021, 11 (1): 13702. doi: 10.1038/s41598-021-93151-6.
Carrière M, Larroque SK, Martial C, Bahri MA, Aubinet C, Perrin F, Laureys S*, Heine L*. An Echo of Consciousness: Brain function during preferred music. Brain Connectivity 2020, 10 (7): 385-395. doi: 10.1089/brain.2020.0744.
Perrin F. Sentir et percevoir. Du coma à l’éveil de coma. In Analysis 2020, 4: 164-168. doi: 10.1016/j.inan.2020.04.003.
Castro M, L’Héritier F, Plailly J, Saive AL, Corneyllie A, Tillmann B*, Perrin F*. Personal familiarity of music and its cerebral effect on subsequent speech processing. Scientific Report 2020, 10: 14854. doi: 10.1038/s41598-020-71855-5.
Perrin F. Les zombies sont en nous. In Zombie : mythe ou réalité ? Editions ActuSF 2020.
Jakubowski K, Eerola T, Tillmann B, Perrin F, Heine L. A cross-sectional study of reminiscence bumps for music-related memories in adulthood. Music & Science 2020, 3 :1-13. doi: 10.1177/205920432096505.
Gobert F, Luauté J, Raverot V, Cotton F, Dailler F, Claustrat B, Perrin F*, Gronfier C*. Is circadian rhythmicity a prerequisite to coma recovery? Circadian recovery concomitant to cognitive improvement in two comatose patients. Journal of Pineal Research 2019, 66 (3): e12555. doi: 10.1111/jpi.12555.
Leclère T, Lavandier M, Perrin F. On the externalization of sound sources with headphones without reference to a real source. The Journal of the Acoustical Society of America 2019, 146 (4): 2309-2320. doi: 10.1121/1.5128325.
Luauté J, Dubois A, Heine L, Guironnet C, Juliat A, Gaveau V, Tillmann B, Perrin F. Electrodermal reactivity to emotional stimuli in healthy subjects and patients with disorders of consciousness. Annals of Rehabilitation and Physical Medicine 2018, 18 pii: S1877-0657(18)30062-9. doi: 10.1016/j.rehab.2018.04.007.
Perrin F, Heine L. Améliorer l’évaluation des patients dans le coma ou en éveil de coma avec la musique. Lettre des Neurosciences 2018.
Heine L, Perrin F. Personally relevant stimuli during assessment of patients with disorders of consciousness. Journal of Rehabilitation Medicine 2018, 50: 668-670. doi: 10.2340/16501977-2342.
Perrin F, Sergent C, Lavandier M, Delorme A, Silva S, Naccache L. Apport de l’électroencéphalographie dans l’évaluation des patients en coma ou en éveil de coma – Le projet CogniComa. In Jourdan C, Pellas F, Luauté J, Chevallier JB, de Boissezon X (Eds), Etats de conscience altérée (pp.81-86). Sauramps Medical, Montpellier, 2018.
Sergent C, Faugeras F, Rohaut B, Perrin F, Wyart V, Valente M, Tallon-Baudry C, Cohen L, Naccache L. Multidimensional cognitive evaluation of patients with disorders of consciousness using EEG: a proof of concept study. NeuroImage: Clinical 2017, 13: 455–469. doi: 10.1016/j.nicl.2016.12.004.
Heine L, Hauet M, Juliat A, Dubois A, Laureys S, Kandel M, Plailly J, Tillmann B, Luauté J, Perrin F. Effects of preference and sensory modality on behavioral reactions in patients with disorders of consciousness. Brain Injury 2017, 31 (10): 1307-1311. doi: 10.1080/02699052.2017.1306108.
Magee WL, Tillmann B, Perrin F, Schnakers C. Music and disorders of consciousness: emerging research, practice and theory. Frontiers in Psychology - Consciousness Research 2016, 7: 1273. doi: 10.3389/fpsyg.2016.01273.
Mathias B, Palmer C, Perrin F, Tillmann B. Sensorimotor learning enhances expectations during auditory perception. Cerebral Cortex 2015, 25 (8): 2238-2254. doi: 10.1093/cercor/bhu030.
Castro M, Tillmann B, Luauté J, Corneyllie A, Dailler F, André-Obadia N, Perrin F. Boosting cognition with music in patients with disorders of consciousness. Neurorehabilitation and Neural Repair 2015, 29 (8): 734-742. doi: 10.1177/1545968314565464.
Perrin F, Castro M, Tillmann B, Luauté J. Promoting the use of personally-relevant stimuli for investigating patients with disorders of consciousness. Frontiers in Psychology - Consciousness Research 2015, 6: 1102. doi: 10.3389/fpsyg.2015.01102.
Heine L, Castro M, Martial C, Tillmann B, Laureys S, Perrin F. Exploration of functional connectivity during preferred music stimulation in patients with disorders of consciousness. Frontiers in Psychology - Consciousness Research 2015 6: 1704. doi: 10.3389/fpsyg.2015.01704.
Selchenkova T, François C, Schön D, Corneyllie A, Perrin F, Tillmann B. Metrical presentation boosts implicit learning of artificial grammar. PlosOne 2014, 9 (11): e112233. doi: 10.1371/journal.pone.0112233.
Verger J, Ruiz S, Tillmann B, Ben Romdhane M, De Quelen M, Castro M, Tell L, Luauté J, Perrin F. Beneficial effect of preferred music on cognitive functions in minimally conscious state patients. Revue Neurologique 2014, 170: 693-699. doi: 10.1016/j.neurol.2014.06.005.
Perrin F, Grimault N. L'audition : acoustique et cerveau. Acoustique & Techniques 2013, 73: 4-6.
Signoret C, Gaudrain E, Perrin F. Similarities in the neural signature for the processing of behaviorally categorized and uncategorized speech sounds. European Journal of Neuroscience 2013, 37 (5): 777-785. doi: 10.1111/ejn.12097.
Peter-Derex L, Perrin F, Petitjean T, García-Larrea L, Bastuji H. Discriminating neurological from psychiatric hypersomnia using the forced awakening test. Neurophysiologie Clinique / Clinical Neurophysiology 2013, 43 (3): 171-179. doi: 10.1016/j.neucli.2013.04.002.
Perrin F. Sur la trace des zombies. Sens-Dessous 2012, 10: 112-118.
Daltrozzo J, Claude L, Tillmann B, Bastuji H, Perrin F. Working memory is partially preserved during sleep. PlosOne 2012, 7 (12): e50997. doi: 10.1371/journal.pone.0050997.
Marmel F, Perrin F, Tillmann B. Tonal expectations influence early pitch processing. Journal of Cognitive Neuroscience 2011, 23 (10): 3095-3104. doi: 10.1162/jocn.2011.21632.
Fellinger R, Klimesch W, Schnakers C, Perrin F, Freunberger R, Gruber W, Laureys S, Schabus M. Cognitive processes in disorders of consciousness as revealed by EEG time-frequency analyses. Clinical Neurophysiolgy 2011, 122 (11): 2177-2184. doi: 10.1016/j.clinph.2011.03.004.
Daltrozzo J, Signoret C, Tillmann B, Perrin F. Subliminal semantic priming in speech. PLoS One 2011, 6 (5): e20273. doi: 10.1371/journal.pone.0020273.
Signoret C, Gaudrain E, Tillmann B, Grimault N, Perrin F. Facilitated auditory detection for speech sounds. Frontiers in Psychology - Auditory Cognitive Neuroscience 2011, 2: 176. doi: 10.3389/fpsyg.2011.00176
Schnakers C, Perrin F, Schabus M, Hustincx R, Majeurs S, Moonen G, Boly M, Vanhaudenhuyse A, Bruno MA, Laureys S. Detecting consciousness in a total Locked-in syndrome: an active event related paradigm. Neurocase 2009, 15 (4): 271–277. doi: 10.1080/13554790902724904.
Schmitz R, Schabus M, Perrin F, Luxen A, Maquet P, Peigneux P. Recurrent boosting effects of short inactivity delays on performance: an ERPs study. BMC Research Notes 2009, 2: 170. doi: 10.1186/1756-0500-2-170.
Vanhaudenhuyse A, Laureys S, Perrin F. Cognitive event-related potentials in comatose and post-comatose states. NeuroCriticalCare 2008, 8 (2): 262-270. doi: 10.1007/s12028-007-9016-0.
Schnakers C, Perrin F, Schabus M, Majeurs S, Ledoux D, Damas P, Boly M, Vanhaudenhuyse A, Bruno MA, Moonen G, Laureys S. Voluntary brain processing in disorders of consciousness. Neurology 2008, 71: 1614-1620. doi: 10.1212/01.wnl.0000334754.15330.69.
Bastuji H, Perrin F, García-Larrea L. Qui dort, écoute. Les Dossiers de la Recherche 2008, 30: 36-39.
Laureys S, Perrin F, Brédart S. Self-consciousness in non-communicative patients. Consciousness & Cognition 2007, 16 (3): 722-741. doi: 10.1016/j.concog.2007.04.004.
Vanhaudenhuyse A, Bruno MA, C Schnackers, Boly M, Boveroux P, Moonen G, Perrin F, Pellas F, Pantke KH, Laureys S. Locked-in syndrome and disorder of consciousness: how to detect consciousness? In Pellas F, Kiefer K, Weiss J, Pélissier J (Eds), Éveil de coma et états limites. États végétatifs, états pauci-relationnels et locked-in syndrome (pp. 109-116). Masson, Issy-les Moulineaux. 2007.
Hoen M, Meunier F, Grataloup C, Grimault N, Perrin F, Perrot X, Pellegrino F, Collet L. Phonetic and lexical interferences in informational masking during speech-in-speech comprehension. Speech Communication 2007, 49 (12): 905-916. doi : 10.1016/j.specom.2007.05.008.
Vanhaudenhuyse A, Schnakers C, Boly M, Perrin F, Brédart S, Laureys S. Détecter les signes de conscience chez le patient en état de conscience minimale. Reanimation 2007, 16 (6): 527-532. doi: 10.1016/j.reaurg.2007.09.010.
Perrin F, Schnakers C, Schabus M, Degueldre C, Goldman S, Brédart S, Faymonville ME, Lamy M, Moonen G, Luxen A, Maquet P, Laureys S. Brain response to one’s own name in vegetative state, minimally conscious state and locked-in syndrome. Archives of Neurology (JAMA Neurology) 2006, 63: 562-569. doi: 10.1001/archneur.63.4.562.
García-Larrea L, Perrin F, Bastuji H. Potentiels évoqués, conscience et encodage mnésique. Étude à l’aide d’un test de réveil force. In Guéguen B, Chauvel P, Touchon J (Eds), Neurophysiologie des mémoires (pp. 207-213). Elsevier, Paris, 2005.
Dang-Vu TT, Desseilles M, Laureys S, Degueldre C, Perrin F, Phillips C, Maquet P, Peigneux P. Cerebral correlates of delta-waves during non-REM sleep revisited. Neuroimage 2005, 28 (1): 14-21. doi: 10.1016/j.neuroimage.2005.05.028.
Maquet P, Ruby P, Maudoux A, Albouy G, Sterpenich V, Dang-Vu TT, Desseilles M, Boly M, Perrin F, Peigneux P, Laureys S. Human cognition during REM sleep and the activity profile within frontal and parietal cortices: a reappraisal of functional neuroimaging data. Progress in Brain Research 2005, 150: 219-227. doi: 10.1016/S0079-6123(05)50016-5.
Laureys S, Pellas F, Van Eeckhout P, Ghorbel S, Schnakers C, Perrin F, Berré J, Faymonville ME, Pantke KH, Damas P, Lamy M, Moonen G, Goldman S. The locked-in syndrome: what is it like to be conscious but paralyzed and voiceless? Progress in Brain Research 2005, 150: 495-511. doi: 10.1016/S0079-6123(05)50034-7.
Laureys S, Perrin F, Schnakers C, Boly M, Majeurs S. Residual cognitive function in comatose, vegetative and minimally conscious states. Current Opinion in Neurology 2005, 18 (6): 726-733. doi: 10.1097/01.wco.0000189874.92362.12.
Laureys S, Perrin F, Faymonville ME, Schnakers C, Boly M, Bartsch V, Majeurs S, Moonen G, Maquet P. Cerebral processing in the minimally conscious state. Neurology 2004, 63 (5): 916-918. doi: 10.1212/01.wnl.0000137421.30792.9b.
Perrin F. Auditory evoked potentials studies of information processing during human sleep. Psychologica Belgica 2004, 44 (1/2): 43-57.
Maquet P, Perrin F, Laureys S, Dang-Vu TT, Desseilles M, Boly M, Peigneux P. Cerebral functional segregation and integration during human sleep. In Luppi PH (Ed), Sleep: Circuits and Functions (pp. 225-238). Boca Raton, FL USA: CRC, 2004.
Perrin F, Peigneux P, Fuchs S, Verhaeghe S, Laureys S, Middleton B, Degueldre C, Del Fiore G, Vandewalle G, Balteau E, Poirrier R, Moreau V, Luxen A, Maquet P, Dijk DJ. Non-visual responses to light exposure in the human brain during the circadian night. Current Biology 2004, 14 (20): 1842-1846. doi: 10.1016/j.cub.2004.09.082.
Peigneux P, Laureys S, Fuchs S, Collette F, Perrin F, Reggers J, Phillips C, Degueldre C, Del Fiore G, Aerts J, Luxen A, Maquet P. Are spatial memories strengthened in the human hippocampus during slow wave sleep? Neuron 2004, 44 (3): 535-545. doi: 10.1016/j.neuron.2004.10.007.
Perrin F, Maquet P, Peigneux P, Ruby P, Degueldre C, Balteau E, Del Fiore G, Moonen G, Luxen A, Laureys S. Neural mechanisms involved in the detection of our first name: a combined ERPs and PET study. Neuropsychologia 2005, 43 (1): 12-19. doi: 10.1016/j.neuropsychologia.2004.07.002.
Perrin F, García-Larrea L. Modulation of the N400 potential during auditory phonological/semantic interaction. Cognitive Brain Research 2003, 17 (1): 36-47. doi: 10.1016/s0926-6410(03)00078-8.
Hudry J, Perrin F, Ryvlin P, Mauguière F, Royet JP. Olfactory short-term memory and related amygdala recordings in patients with temporal lobe epilepsy. Brain 2003, 126 (8): 1851-1863. doi: 10.1093/brain/awg192.
Maquet P, Laureys S, Perrin F, Ruby P, Melchior G, Boly M, Dang-Vu TT, Desseilles M, Peigneux P. Festina lente: evidences for fast and slow learning processes and a role for sleep in human motor skill learning. Learning & Memory 2003, 10 (4): 237-239. doi: 10.1101/lm.64303.
Bastuji H, Perrin F, García-Larrea L. Qui dort, écoute. La Recherche 2003, 366: 67-69.
Bastuji H, Perrin F, García-Larrea L. Event-related potentials during forced awakening: a tool for the study of acute sleep inertia in patients with excessive daytime sleepiness. Journal of Sleep Research 2003, 12 (3): 189-206. doi: 10.1046/j.1365-2869.2003.00358.x.
Perrin F, García-Larrea L, Bastuji H. Detection of verbal discordances during sleep. NeuroReport 2002, 13 (10): 1345-1349. doi: 10.1097/00001756-200207190-00026.
Perrin F, Bastuji H. Le test de réveil forcé : évaluation combinée de la somnolence et de l'inertie de sommeil chez les patients narcoleptique ou hypersomniaque. Paradoxalement Vôtre 2002, 39: 5-6.
Laureys S, Peigneux P, Perrin F, Maquet P. Sleep and Motor Skill Learning. Neuron 2002, 35 (1): 5-7. doi: 10.1016/s0896-6273(02)00766-3.
Bastuji H, Perrin F, García-Larrea L. Semantic analysis of auditory input during sleep: studies with event-related potentials. International Journal of Psychophysiology 2002, 46 (3): 243-255. doi: 10.1016/s0167-8760(02)00116-2.
Perrin F, García-Larrea L. Électrophysiologie cognitive et troubles du développement du langage chez l'enfant. ANAE 2001, 61: 18-20.
Perrin F, García-Larrea L, Bastuji H. Études électrophysiologiques des capacités et limites de discrimination sémantique du cerveau endormi. Bulletin Veille & Sommeil - Europe 2001, 9: 38-44.
García-Larrea L, Perchet C, Perrin F, Amanedo E. Interference of cellular phone conversations with visuomotor tasks: an ERP study. Journal of Psychophysiology 2001, 15: 14-21. doi: 10.1027//0269-8803.15.1.14.
Perrin F, Bastuji H, Mauguière F, García-Larrea L. Functional dissociation of the early and late portions of human K-complexes. NeuroReport 2000, 11 (8): 1637-1640. doi: 10.1097/00001756-200006050-00008.
Perrin F, García-Larrea L, Mauguière F, Bastuji H. A differential brain response to the subject’s own name persists during sleep. Clinical Neurophysiolgy 1999, 110 (12): 2153-2164. doi: 10.1016/s1388-2457(99)00177-7.
