PhD Defense thesis Yanlong HOU “Non-visual mechanisms involved in sleep-wake regulation by light in mice and humans”

Hello everyone,
 

I'm pleased to invite you to my thesis defense, which will take place next Monday (December 2) at 2 pm in the Bibliothèque DYCOG (Bâtiment 452,opposite CRNL Building). My thesis is entitled “Non-visual mechanisms involved in sleep-wake regulation by light in mice and humans”.( The presentation will be in English).
 

The jury will be composed of:

Christina SCHMIDT (Reporter), Véronique FABRE (Reporter), Patricia FRANCO (Examiner), Patrice BOURGIN (Examiner) and my thesis supervisors: Claude GRONFIER and Jian-Sheng LIN.

Abstract:Sleep and wakefulness are governed by the circadian and homeostatic systems, with natural sunlight regulating the former and prior wakefulness influencing the latter. While extended illumination benefits modern life, it also disrupts sleep, mood, cognition, and increases risks of metabolic and cardiovascular diseases. My thesis investigated artificial light's effects on sleep-wake regulation in mice and humans. In mice, light-induced slow-wave sleep and delta cortical activity were dependent on histamine and orexin, with histamine playing a key role. In humans, low-intensity artificial light (20 lux) during sleep fragmented sleep, raised body temperature and glucose levels, and affected next-morning light sensitivity and cognition. These findings highlight the importance of reducing nighttime light exposure through interventions like closing windows or using eye masks, with further research needed on long-term effects and mechanisms.
 

For those unable to attend in person, the defense will also be accessible via Teams.

A buffet will be held at the end of the presentation (all are welcome).

We hope to see you soon,