Conférence Chaire Labex Cortex - Deivid Rodrigues "Towards the understanding of human neurodevelopment and its disorders through the lenses of RNA metabolism"

RNA metabolism programs such as mRNA decay and translation regulation provide extra regulatory  layers  to  gene  expression  and  are  critical  for  brain  development  and  function. Together with ‘development’ and ‘synaptic function’, RNA metabolism is consistently impacted in  the  neuronal  cells  of  patients  with  neurodevelopmental  disorders  imposing  physiological outcomes not predicted by studies of transcription and mRNA levels. Using human iPSC-based 2D  and  3D  neurodevelopmental  models  and  multi-OMICS  approaches,  Dr.  Rodrigues characterized the post-transcriptional regulation of key neurodevelopmental-related genes, the extent  of  translation  regulation  during  neurodevelopment,  and  an  unsuspected  interplay between transcription and mRNA decay in neurodevelopmental disorders. Dr. Rodrigues’ aims are to further broaden our understanding of RNA metabolism in health and disease states of neurodevelopment and devise mechanism-inspired strategies for translational applications.

Inscription gratuite et obligatoire sur https://evento.renater.fr/survey/chair-of-excellence-seminars-78i5ykb0