<!-- THEME DEBUG --> <!-- THEME HOOK: 'block' --> <!-- FILE NAME SUGGESTIONS: ▪️ block--crnl2019-page-title.html.twig ✅ block--page-title-block.html.twig ▪️ block--core.html.twig ▪️ block.html.twig --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/block/block--page-title-block.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'page_title' --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/system/page-title.html.twig' --> <h1 class="page-header"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: ▪️ field--node--title--equipes.html.twig ✅ field--node--title.html.twig ▪️ field--node--equipes.html.twig ▪️ field--title.html.twig ▪️ field--string.html.twig ▪️ field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>WAKING</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> </h1> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/system/page-title.html.twig' --> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/block/block--page-title-block.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'block' --> <!-- FILE NAME SUGGESTIONS: ▪️ block--crnl2019-content.html.twig ▪️ block--system-main-block.html.twig ✅ block--system.html.twig ▪️ block.html.twig --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/block/block--system.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'node' --> <!-- FILE NAME SUGGESTIONS: ▪️ node--40--full.html.twig ▪️ node--40.html.twig ▪️ node--equipes--full.html.twig ▪️ node--equipes.html.twig ▪️ node--full.html.twig ✅ node.html.twig --> <!-- 💡 BEGIN CUSTOM TEMPLATE OUTPUT from 'themes/crnl2019/templates/node/node.html.twig' --> <article data-history-node-id="40" class="equipes full clearfix"> <div class="content"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: ▪️ links--node.html.twig ✅ links.html.twig --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: ▪️ field--node--field-descriptif-court--equipes.html.twig ▪️ field--node--field-descriptif-court.html.twig ▪️ field--node--equipes.html.twig ▪️ field--field-descriptif-court.html.twig ▪️ field--text.html.twig ✅ field.html.twig --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <div class="field field--name-field-descriptif-court field--type-text field--label-hidden field--item">Integrated Physiology of the Brain Arousal Systems</div> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: ▪️ field--node--field-objectifs--equipes.html.twig ▪️ field--node--field-objectifs.html.twig ▪️ field--node--equipes.html.twig ▪️ field--field-objectifs.html.twig ▪️ field--text-long.html.twig ✅ field.html.twig --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <div class="field field--name-field-objectifs field--type-text-long field--label-above"> <div class="field--label">Objectives</div> <div class="field--item"><p><strong>Our goal is to unravel the mechanisms of wakefulness and associated sleep/wake pathologies, combining both basic and translational research.</strong></p><p>Wakefulness - as well as sleep – is a highly integrative function that relies on dedicated neuronal networks and is modulated by ongoing behavioral, neurodevelopmental, environmental, as well as cellular, molecular and metabolic signals.</p><p>We thus investigate the brain arousal systems and regulatory networks in various behavioral contexts during waking, its impact on the local regulation of cortical activity and on molecular/genetic signaling.</p><p>Our human and clinical research investigates how sleep, wakefulness and non-visual functions are regulated by light and the circadian clock. It also addresses the impact of sleep and sleep disorders on human health in adults and children.</p><p>We also investigate physiopathology and therapy of sleep/wake disorders, notably narcolepsy and excessive daytime sleepiness.&nbsp;</p><img data-entity-uuid="1fe31d6d-602e-4770-a49b-f14e0defb92f" data-entity-type="file" src="/sites/default/files/inline-images/image_4.png" alt="Scheme" width="1242" height="618"></div> </div> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: ▪️ field--node--field-methodes-techniques--equipes.html.twig ▪️ field--node--field-methodes-techniques.html.twig ▪️ field--node--equipes.html.twig ▪️ field--field-methodes-techniques.html.twig ▪️ field--text-long.html.twig ✅ field.html.twig --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <div class="field field--name-field-methodes-techniques field--type-text-long field--label-above"> <div class="field--label">Methods and Techniques</div> <div class="field--item"><p><strong>In mice</strong> : sleep/wake EEG analysis, pharmacological and behavioral tests, toxoplasma-infection model, optogenetics, DREADD, immuno-histology. &nbsp;</p><p><strong>In Drosophila</strong> : molecular genetics, sleep/wake monitoring, metabolic and behavioral tests, immuno-histology.</p><p><strong>In humans</strong> : polysomnography, sleep/wake EEG analysis across lifespan and in healthy individuals and patients, circadian rhythms (constant routine), chronotyping, circadian phase assessment (Dim Light Melatonin Onset), non-visual responses to light, hormonal profiling (melatonin, cortisol, etc.), clock genes, melanopsinergic responses, behavioral/cognitive and physiological tests, mathematical modeling, statistical analysis of complex databases, pupillary reflex, visual performance, body temperature, visual discomfort, &nbsp;pain, mood, CSF analysis, clinical trials in children and adults.</p></div> </div> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: ▪️ field--node--field-projets-recherche--equipes.html.twig ▪️ field--node--field-projets-recherche.html.twig ▪️ field--node--equipes.html.twig ▪️ field--field-projets-recherche.html.twig ▪️ field--text-long.html.twig ✅ field.html.twig --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <div class="field field--name-field-projets-recherche field--type-text-long field--label-above"> <div class="field--label">Research Project</div> <div class="field--item"><p><strong>Our current investigations address:</strong></p><ol><li>the differential involvement of the histaminergic and orexinergic systems in various behavioral contexts during waking and sensory perception via thalamocortical dynamics;</li><li>the role of amino-acid transport and neuroglial signaling in the modulation of networks associated with wakefulness and behavioral performance;</li><li>the role of light- and circadian clock-driven mechanisms in wake regulation;</li><li>the impact of waking systems (orexin, histamine) deficiency in the physiopathology of sudden infant death syndrome and in childhood narcolepsy, novel diagnostic and therapeutic concepts on sleep disorders. &nbsp;</li></ol><p>The WAKING research projects include the use and development of state-of-the-art technologies in animal models (mouse, Drosophila) and in humans from infancy to adulhood. The projects have received funding including ANR, CPER, Idex Breakthough and industrial grants.</p><p><strong>In addition, the WAKING team has been selected for the renewed LABEX CORTEX starting in 2020 and our associated clinical group is recognized as national reference center for narcolepsy.&nbsp;</strong></p><p>&nbsp;</p></div> </div> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: ▪️ field--node--field-adresse--equipes.html.twig ▪️ field--node--field-adresse.html.twig ▪️ field--node--equipes.html.twig ▪️ field--field-adresse.html.twig ▪️ field--text-long.html.twig ✅ field.html.twig --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <div class="field field--name-field-adresse field--type-text-long field--label-above"> <div class="field--label">Contact</div> <div class="field--item"><p>Laurent SEUGNET - laurent.seugnet@inserm.fr</p><p>Jian-Sheng LIN - js.lin@inserm.fr</p></div> </div> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: ▪️ field--node--field-reftax-transvers--equipes.html.twig ▪️ field--node--field-reftax-transvers.html.twig ▪️ field--node--equipes.html.twig ▪️ field--field-reftax-transvers.html.twig ▪️ field--entity-reference.html.twig ✅ field.html.twig --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <div class="field field--name-field-reftax-transvers field--type-entity-reference field--label-above"> <div class="field--label">Transverse Axis</div> <div class="field--items"> <div class="field--item"><a href="/en/taxonomy/term/40?language=fr" hreflang="en">Neural Network Dynamics</a></div> <div class="field--item"><a href="/en/taxonomy/term/43?language=fr" hreflang="en">Life-span Development</a></div> <div class="field--item"><a href="/en/taxonomy/term/45?language=fr" hreflang="en">Naturalistic Neuroscience</a></div> <div class="field--item"><a href="/en/taxonomy/term/42?language=fr" hreflang="en">Neuroscience and Education</a></div> </div> </div> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: ▪️ field--node--field-taxo-thematique-recherche--equipes.html.twig ▪️ field--node--field-taxo-thematique-recherche.html.twig ▪️ field--node--equipes.html.twig ▪️ field--field-taxo-thematique-recherche.html.twig ▪️ field--entity-reference.html.twig ✅ field.html.twig --> <!-- BEGIN OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> <div class="field field--name-field-taxo-thematique-recherche field--type-entity-reference field--label-above"> <div class="field--label">Themes</div> <div class="field--items"> <div class="field--item"><a href="/en/taxonomy/term/47?language=fr" hreflang="en">Perception, Attention, Action</a></div> <div class="field--item"><a href="/en/taxonomy/term/48?language=fr" hreflang="en">Memory, Emotion, Social Cognition</a></div> <div class="field--item"><a href="/en/taxonomy/term/41?language=fr" hreflang="en">Sleep, wakefulness and consciousness</a></div> <div class="field--item"><a href="/en/taxonomy/term/49?language=fr" hreflang="en">Pathophysiology</a></div> <div class="field--item"><a href="/en/taxonomy/term/50?language=fr" hreflang="en">Biomarkers and Prediction</a></div> <div class="field--item"><a href="/en/taxonomy/term/51?language=fr" hreflang="en">Drug Therapy</a></div> <div class="field--item"><a href="/en/taxonomy/term/52?language=fr" hreflang="en">Non-pharmacological rehabilitation and therapies</a></div> </div> </div> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/field/field.html.twig' --> </div> </article> <!-- END CUSTOM TEMPLATE OUTPUT from 'themes/crnl2019/templates/node/node.html.twig' --> <!-- END OUTPUT from 'themes/contrib/bootstrap/templates/block/block--system.html.twig' -->